About
Doctoral Researcher · Toxicology · Scientific Evidence
Ardie Barry Sailis
Department of Pharmaceutical Life Sciences
Faculty of Pharmacy, Universiti Malaya
Kuala Lumpur, Malaysia
ORCID 0009-0009-8994-2793 Scopus ID 60192026900
Researcher. Scientific writer. Evidence‑focused problem solver.
I study how inhaled toxicants, especially e-cigarette aerosol, affect male reproductive health and the molecular mechanisms behind it.
YAP/TAZ as a mechanochemical signal-resolution circuit
A framework for YAP/TAZ that links mechanical sensing, signal integration, temporal decoding, active termination and recovery of mechanosensitivity.
Output depends on signal duration, nuclear residence, context and feedback, not nuclear abundance alone.
Force relaxation and trafficking lower activity, while AMOT stabilization and degradation lock in the OFF state.
The signal is decoded, ended and the mechanical baseline recovers.
Residual chromatin, cytoskeletal, metabolic or matrix changes bias later responses.
Use reversible perturbations, live-cell reporters, timed YAP/TAZ control and joint readouts of signaling, transcription, chromatin and mechanics.
Inhaled toxicants
Characterize what is inhaled, set dose and context, trace the biological response, then judge human relevance.
- ExposureAerosol, tobacco, route
- Dose & contextConcentration, timing
- Biological responseOrgan, cell, pathway
- Human relevanceRisk, uncertainty
Which constituents, particles and doses are plausible.
Respiratory, reproductive, metabolic and systemic endpoints.
Plausibility, mechanism and proven human effects, kept apart.
Molecular mechanisms
Follow the causal chain from a trigger through molecular nodes to adaptation, feedback, termination or lasting dysfunction.
- TriggerStress, ligand, force
- Molecular nodeReceptor, kinase, factor
- Network responseFeedback, crosstalk
- ResolutionAdaptation, persistence
Redox sensing and environmental response.
Force, transcription and cell state.
Signal timing and kinetic filtering.
Evidence & scientific communication
Turn a broad question into an auditable chain: find the literature, test its quality, map claims to evidence and state the conclusion precisely.
- QuestionScope the claim
- RetrieveFind the evidence
- AppraiseQuality, bias
- SynthesizeClaim and uncertainty
Trace each statement to evidence that actually supports it.
Show methods, limits, effect direction and uncertainty.
Cellular Signaling as Dynamic Regulatory Circuits
Four connected papers model YAP/TAZ, NRF2–KEAP1, CYP1A1 and transcriptional condensates as dynamic control systems, not simple switches.
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Latest News
- Oct 2026 New review in Progress in Biophysics and Molecular Biology proposing YAP/TAZ as a mechanochemical signal-resolution circuit.
- Oct 2026 Updated the whole website.
- Oct 2026 Presented my PhD thesis seminar.
- Aug 2026 New paper in Journal of Applied Toxicology on how metal-containing nanoparticles from e-cigarettes may harm male reproduction through mitochondria.
- Aug 2026 New paper in Gene Reports on transcriptional condensates as kinetic filters for gene expression.
For academic correspondence, use the Contact page. Updated 18 October 2026.